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TY - JOUR
TI - Non-antibiotic Antimicrobial Agents to Combat Biofilm-forming Bacteria
AU - Cao, Yuxue
AU - Naseri, Mahdi
AU - He, Yan
AU - Xu, Chun
AU - Walsh, Laurence J.
AU - Ziora, Zyta M.
T2 - Journal of Global Antimicrobial Resistance
AB - Biofilms can be produced by multiple species or by a single strain of bacteria. The biofilm state enhances the resistance of the resident microorganisms to antimicrobial agents by producing extracellular polymeric substances. Typically, antibiotics are used to stop the growth of bacteria, but emerging resistance has limited their effectiveness. Bacteria in biofilms are less susceptible to antibiotics compared with their free-floating state, as biofilms impair antibiotic penetration. To obviate this challenge, non-antibiotic antimicrobial agents are needed. This review describes two classes of these agents, namely antimicrobial nanoparticles and antimicrobial peptides. Applications of these antimicrobials in the food industry and medical applications are discussed, and the directions for future research are highlighted.
DA - 2019/12/10/
PY - 2019
DO - 10.1016/j.jgar.2019.11.012
DP - ScienceDirect
J2 - Journal of Global Antimicrobial Resistance
LA - en
SN - 2213-7165
UR - http://www.sciencedirect.com/science/article/pii/S2213716519303042
Y2 - 2019/12/16/07:53:28
KW - Antimicrobial
KW - Bacteria
KW - Biofilm
KW - Non-antibiotic
ER -