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journalArticle Xu Yikang Dhaouadi Yousr Stoodley Paul Ren Dacheng Sensing the unreachable: challenges and opportunities in biofilm detection Bacteria can attach to essentially all materials and form multicellular biofilms with high-level tolerance to antimicrobials. Detrimental biofilms are responsible for a variety of problems ranging from food and water contamination, bio-corrosion, to drug resistant infections. Besides the challenges in control, biofilms are also difficult to detect due to the lack of biofilm-specific biomarkers and methods for non-destructive imaging. In this article, we present a concise review of recent advancements in this field, with a focus on medical device-associated infections. We also discuss the technologies that have potential for non-destructive detection of bacterial biofilms. 79-84 August 1, 2020 en Sensing the unreachable http://www.sciencedirect.com/science/article/pii/S0958166919301089 2019-11-25 07:53:51 ScienceDirect Current Opinion in Biotechnology 64 Current Opinion in Biotechnology DOI 10.1016/j.copbio.2019.10.009 ISSN 0958-1669